What Does Cancer Mutations Affect Signal Pathways

Cancer Mutations Affect Signal Pathways Oncogenic transformations can make the influenced qualities be overexpressed or deliver changed proteins whose movement is dysregulated. Then again, cancellations and different changes can inactivate negative controllers that regularly work as tumor silencer. Numerous tumor silencers work as negative controllers of cytoplasmic motioning for instance, the adenomatous polyposis coli protein (APC) is a negative controller of the Wnt pathway, and the lipid phosphatase PTEN is negative controller of the P13K-Akt pathway. Authoritative of receptor tyrosine kinases to the suitable ligand causes redesign of the receptors and autophosphorylation of tyrosines in the intracellular part of the particles.†¦show more content†¦Advance downstream, changes in the tumor silencers TSC1 and TSC2 hyper initiate motioning by mTORC1 (Laplante and Sabatini 2012). This is a critical focus of P13K-Aktsignaling. Additionally, the Ras-ERK pathway is enacted by transformations in Ras, or its downstream target Raf, that reason constitutive initiation of these proteins or by inactivation of GTPase-actuating proteins (Holes, for example, NF1, that empower the hydrolysis of GTP bound to Ras, which prompt its inactivation (Cichowski,2001). The interpretation factor Myc is an essential downstream focus of Ras-ERK flagging and numerous different pathways. It is much of the time opened up or overexpressed in malignancy; strangely, Myc can tie to promoter areas of qualities as well as upgrade transcriptional extension of polymerase II, in this manner expanding its belongings past qualities with Myc-restricting destinations in their promoters. Myc can fill in as an all inclusive intensifier of communicated qualities as opposed to simply authoritative to promoters and starting interpretation (Sever and Brugge, 2015). Development factor and cytokine flagging can impact the improvement of a few malignancy sorts. One of the key players in the improvement of tumor is Janus kinas (JAK) flagShow MoreRelatedCancer : A Common Misconception About Cancer5956 Words   |  24 Pagesâ€Æ' INTRODUCTION What is Cancer? A common misconception about cancer is that it is a relatively new disease. Cancer, like many diseases have been prevalent in the populations of many species, not just humans, for millennia. In fact it was a Roman doctor who translated the Greek word â€Å"carcinos† into â€Å"cancer†, a Latin word meaning â€Å"crab†. The reason why cancer is referred to as a crab is because a cancer â€Å"adheres to any part that it seizes upon in an obstinate manner like a crab† (Ramzi S. Cotran etRead MoreWerner Syndrome : Disease Overview1656 Words   |  7 Pageswhich a mutation occurs on the Werner Syndrome RecQ Like Helicase (WRN) gene (Online https://rarediseases.org/rare-diseases/werner-syndrome accessed 30 October, 2016). There prevalence of this disease in less than 10/1,000,000, with higher occurrence among the Japanese population with a frequency of 1/50,000 (Ishikawa et al. 2000). The WRN gene is involved in DNA metabolic pathways such as DNA repair and als o displays an important interaction with telomeres and the p53 protein. Thus, the mutation forRead MoreRadiation Therapy And Its Effects On Cancer1783 Words   |  8 Pages Along with or in place of chemotherapy, patients may need to receive radiation treatments to successfully rid themselves of cancer. The National Cancer Institute explains that radiation therapy, also called radiotherapy, â€Å"uses high-energy radiation to shrink tumors and kill cancer cells.† The Institute also describes the different forms of radiation used, including gamma rays, x-rays, or other beams of charged particles (â€Å"Radiation†). Like chemotherapy, the goal of radiotherapy is to damage theRead MoreTraditional and modern approaches to cancer therapy all act by exploiting some molecular1900 Words   |  8 Pagesmodern approaches to cancer therapy all act by exploiting some molecular abnormality that distinguishes cancer cells from healthy living cells. Cancer cells often acquire defects in the cell-cycle control systems that normally respond to DNA damage by activating apoptosis (programmed cell death) hence cancerous cells continue to grow and multiply d espite containing faulty DNA, making them genetically unstable. Genetic instability may refer to any combination of genome mutations that cause irregularitiesRead MoreUv Radiation And Its Effects1895 Words   |  8 PagesUV radiation, such as that from the sun can be very harmful. It has been shown to cause many different mutations within cells, leading to issues for the organism such as death or disease. One of the most prevalent sources of UV radiation for humans is the sun. It’s very important for us to know the extent of cellular damage that can be caused by this radiation, as to know how harmful the sun’s rays are to us as humans. One way that the damage caused by the suns radiation can be tested is throughRead MoreSkin Cancer1966 Words   |  8 Pagesnice, dark tan, however, they dont know the dangers entailed Skin cancer is the most common type of cancer in the United States. It is the abnormal growth of cells in the skin. There are two different types of skin cancers: Melanomas and non-melanomas. Most skin cancers are the non-melanoma type. There are two main types of non-melanoma skin cancer: basal cell carcinoma and squamous cell carcinoma. Most non-melanoma skin cancers are basal cell carcinoma. It can damage deeper tissues, such as musclesRead MoreSpecific Aim 2: To Determine If Gleevec Is Effective In1404 Words   |  6 Pagesyellow (Almuhaideb et al., 2011). This process will enable us to see the site of any metastatic cancer in any of the mice and provide a rough quantitative estimate of the metastasis that could form. Abl is known to mutate its kinase domain so that Gleevec cannot effectively inhibit it and cellular proliferation (Lovera et al., 2015). A western blot will be run to determine the extent this mutation will affect our experiment at the beginning and 4 months into our experiment. Some tumors from all threeRead MoreA Research On The Myeloid Leukemia4925 Words   |  20 Pagesand friends affected by blood cancers, and I am interested in better understanding the mechanisms of this disease. Advertisement/Pitch: Picture yourself at a check-up appointment with your oncologist. You are told the chemotherapy is not responding. You feel weaker each day. You cannot see straight, you feel dizzy, and you pray that you will find a match for a bone marrow transplant. This is the reality that AML patients face. AML poses the greatest risk to cancer survivors who develop this diseaseRead MoreChapter 13 Review9122 Words   |  37 Pagesof variations in the animals condition. What do we call this type of gene? constitutive gene 11 Liver cells, mammary cells, and skin cells all contain the same genome; however, their respective proteomes vary drastically. This observation is best explained by what phenomenon? cell differentiation 12 Which of the following are points of control for gene expression in eukaryotes? all choices correct 13 What type of regulatory transcription factorRead MoreAccording to Inderjeet Dokal there are currently 13 known variations of genes that cause FA and2400 Words   |  10 PagesFANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, FANCM, and FANCN† (Dokal, 2008). Dokal and many other doctors agree that FA is a very penetrant genetic disorder. That is, all of these subtypes of the FA gene can cause many of the different types of cancer and bone marrow deficiencies that are associated with FA. For example, in the list given by Dokal, the subtype FANCA is known to express as a gene that controls certain aspects of protein coding. This one genetic subtype causes breakdowns in the various

Where Is the Diversity in America Today Free Essays

The dream of a diverse America has to be one of the most fundamental philosophies on which our country has been built. From the first group of pilgrims that landed at Plymouth Rock, to the thousands that immigrate to America every year, they all still believe in the same dream that the pilgrims had when they came to America. The Dream that no matter what their racial, religious, or social background and beliefs are they can find wealth and happiness in America. We will write a custom essay sample on Where Is the Diversity in America Today or any similar topic only for you Order Now This philosophy was so important that our Founding Fathers had to mention it in the Constitution. Yet nearly two and half centuries later where is that diversity in America today? It seems that even with the population of America at over 300 million today we are still like the first groups of Pilgrims, content to stay within our own little groups. As a conscious America we talk a good game, however when we go home at night our subconscious takes over, and we retreat into that comfort zone within our group. American’s should admit that they really don’t care about anyone else except themselves. They should stop pretending that they do, unless they can actually live by the example that our conscious mind has us profess. According to the 2000 Census report the composite of races in America today are basically 75% White, 12. 3% Black, 12. 5% Hispanic or Latino, with Native Americans and other races making up the rest of our population. One can see from these numbers that it would be very easy to segregate into racial groups and to live within one group. The Columbia Encyclopedia’s unsigned essay on race which happens to be titled Race points out how we classify groups strictly by our physical characteristics and even argues that the term race is an inappropriate term; Race says that many physical anthropologists believe: â€Å"The term race is inappropriate when applied to national, religious, geographic, linguistic or ethnic groups, nor can the biological criteria of race be equated with any mental characteristics such as intelligence, personality, or character. (263). Still those social distinctions like living with your own race, having all your friends of the same race and background, and even maybe those who are only in the same tax bracket or educational level prevail in our society today, and is not only natural for people to gravitate towards a comfort zone that they find within themselves and their environment? The answer would have to be yes, this means certain social distinctions do in fact matter. There is Religion in America today, which may not be viewed as one of those important factors of our social make-up as it once was, but when we take a look at the population numbers which profess that Christians and of other religious beliefs are in the majority that make up Americans today; we do have to admit it does play an important role. Probably not as much as in Europe or in some other countries, but Religion is an important factor none the less. According to the U. S. Census Bureau we have an adult population of: approximately 207 million, approximately 159 million are Christians, approximately 8 million in other religions, and approximately 29 million who believe in something other than a specified religion. With this data we can see that the majority of America’s social make-up is indeed Christian. This provides the American culture with very specific views and customs. Since religion is one of those fundamental beliefs that founded our country it is easy to see how it becomes a major factor in determining how we act and live in our society today. The facts are that your social background can predetermine your future. David Brooks, a senior editor for The Weekly Standard and who publishes frequently in Atlantic Monthly, Newsweek, and The New York Times, says it best in one of his essays People Like Us, when he says: â€Å"Human beings are capable of drawing amazingly subtle social distinctions and then shaping their lives around them. (253). Truly we shape our lives based on our environment and our beliefs that are familiar to us and we are raised within. That is why people tend to stay with their own group based on the color of their skin, religious beliefs, and social background. We see it everyday in our conscious life, where we go to work, school, shop, or relax. All these are influenced by those subtle social distinctions that make up our lives. Bringing all of these facts together, we can only conclude that man is a driven being. One driven by his environment, and that just by the luck of the social economic environment they were born into predetermines for the most part where they will live, work, and also which religion they will choose to follow. We can almost go as far as to determine the tax bracket into which they will fall. So when is America going to wake and realize that the only way to find diversity is to come to some happy medium with our conscious and subconscious mind? Change that is not to dramatic, but change none the less, seems to be the only answer. How to cite Where Is the Diversity in America Today, Essay examples

Highlights Case Of Negligence And Possible â€Myassignmenthelp.Com

Question: Discuss About The Highlights Case Of Negligence And Possible? Answer: Introducation Negligence can be defined in the simplest forms as such a breach of the obligation of care owed by one person to some other person. This has to include the harm, loss or injury to the person to which the duty of care was owed due to the actions undertaken by the individual who owed a duty to care to such injured or harmed party (Greene, 2013). In order to make a case of negligence before a court of law, the plaintiff is required to show that there had been a duty of care owed to him, which had been violated, which caused harm/ loss/ injury, and was not only foreseeable in a reasonable manner but was also not too remote, in addition to the presence of proximity between the parties and a direct causation between the breached duty and the injury/ harm/ loss of the plaintiff (Statsky, 2011). For establishing duty of care, proximity, reasonable foreseeability and contravention of duty of care, the English case of Donoghue v Stevenson [1932] UKHL 100 proves to be of help. In this case, Donoghue drank the ginger beer from the bottle which was manufactured by the defendant of this case, Stevenson. As a dead snail was present inside this bottle, the drink was contaminated and upon drinking the same, Donoghue fell sick and sued for compensation under tort of negligence committed by Stevenson. However, Stevenson denied owing a duty to Donoghue (Lunney and Oliphant, 2013). The court held otherwise and stated that a duty of care was owed by Stevenson due to the proximity of relationship between a consumer and the manufacturer of the product. Further, this risk of harm was reasonably foreseeable due to the fact that a contaminated bottle was bound to make the consumer sick. As the manufacturer failed to ensure the safety of thee ginger beer, he contravened his obligation of care a nd was asked to compensate Donoghue for her losses (Latimer, 2012). Whenever a case of negligence is made, a common defence which is cited is that of volenti non fit injuria. As per this concept, the plaintiff of the case, i.e., the person who has been injured as a result of the negligence of other knowingly takes the risk even when they are clearly aware of the fact that the risk of harm/ injury/ loss was present. When this defence is present, the claim of negligence is not upheld (Turner, 2013). In the case of ICI Ltd v Shatwell [1965] AC 656, the brother had been injured due to the explosion of the quarry of the defendant which was a result of the negligence of the brother. A worker had gone to get more wire yet they did not wait for him and tested with a shorter wire. When the explosion occurred, they made a claim against the defendant on the basis of concept of vicarious liability of the employer for negligence and also for violating the statutory duty to the other brother. However, the defendant raised the defence under volenti non fit injuria and presented that they had clear knowledge of risk and that they had acted against the express instructions given to them. The court upheld this defence and quashed the claims of the brothers (E-Law Resources, 2017). When it comes to such cases where driving under the influence of alcohol is involved, and where an accident is caused as a result of it, it is clear that such accidents occur due to the diminished ability of the driver. And this often gives rise to claims of negligence. However, the passengers also owe certain responsibility in such cases and where they wilfully accept ride from a drunk driver, their claim can be quashed due to the defence of volenti non fit injuria (Navin, 2016). An example of such occurrence is the case of Insurance Commissioner v Joyce [1948] HCA 17; (1948) 77 CLR 39. In this case, the passenger had clear knowledge that the driver was under the influence of alcohol and had been inebriated as a result of drinking. And still, the passenger took the ride from the plaintiff voluntarily, without any pressure. Hence, the High Court ruled in favour of the defendant and stated that negligence cannot be claimed by the plaintiff as they voluntarily assumed the risk of harm (Jade, 2017). Application The facts of this case study reveal that Michelle was under the influence of alcohol and Rebecca clearly knew this as they had consumed the wine at the concert together. Rebecca can make a claim of negligence against Michelle for driving under influence of alcohol on the basis of Donoghue v Stevenson and claim that a duty of care was owed by Michelle as driving under alcohol influence is bound to cause an accident and is reasonably foreseeable. Further, the driver and passenger do have proximity of relationship and Rebecca was also injured. However, the chances of this claim being deemed as a success are less. This is due to the fact that Michelle can opt for the defence of volenti non fit injuria. Applying ICI Ltd v Shatwell, Rebecca had voluntarily assumed the risk so her claim of negligence against Michelle would be cancelled. Applying Insurance Commissioner v Joyce, this point is strengthened as she had voluntarily assumed the ride from Michelle. Even though she raised her voice later on, but that was only when Michelle drove riskily, but till then, she had already assumed the risk. Hence, her claim of negligence against Michelle is not likely to be upheld. Conclusion Due to the success of volenti non fit injuria, Rebeccas claim against Michelle would fail and Michelle would not have to compensate her for negligence. References E-Law Resources. (2017) Imperial Chemical Industries Ltd v Shatwell [1965] AC 656 House of Lords. [Online] E-Law Resources. Available from: https://www.e-lawresources.co.uk/Imperial-Chemical-Industries-Ltd-v-Shatwell.php [Accessed on: 13/09/17] Greene, B. (2013) Course Notes: Tort Law. Oxon: Routledge. Jade. (2017) Insurance Commissioner v Joyce. [Online] Jade. Available from: https://jade.io/article/64545 [Accessed on: 13/09/17] Latimer, P. (2012) Australian Business Law 2012. 31st ed. Sydney, NSW: CCH Australia Limited. Lunney, M., and Oliphant, K. (2013) Tort Law: Text and Materials. 5th ed. Oxford: Oxford University Press. Navin, M. (2016) Values and Vaccine Refusal: Hard Questions in Ethics, Epistemology, and Health Care. Oxon: Routledge. Statsky, W.P. (2011) Essentials of Torts. 3rd ed. New York: Cengage Learning. Turner, C. (2013) Unlocking Torts. 3rd ed. Oxon: Routledge.